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Changes in your heart rate or rhythm, such as a fast, slow, pounding or skipping heartbeat; DrugBank Accession Number DB06204 Background Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake 2, 3 Tapentadol was first approved by the FDA on November 20, 2008 The extended-release formulation of tapentadol was also approved --- drugs com sfx tapentadol-side-effects html Tramadol has an average rating of 7 0 out of 10 from a total of 1861 ratings on Drugs com 62% of reviewers reported a positive effect, while 24% reported a negative effect Tapentadol has an average rating of 6 3 out of 10 from a total of 425 ratings on Drugs com 53% of reviewers reported a positive effect, while 29% reported a negative effect --- webmd com drugs 2 drug-152563 nucynta-oral detailsCommon tapentadol side effects may include: constipation, nausea, vomiting, stomach pain; headache, feeling tired; or drowsiness, dizziness This is not a complete list of side effects and others may occur Call your doctor for medical advice about side effects You may report side effects to FDA at 1-800-FDA-1088 Aug 23, 2023 · Common tapentadol side effects may include: constipation, nausea, vomiting, stomach pain; headache, feeling tired; or drowsiness, dizziness This is not a complete list of side effects and others may occur Call your doctor for medical advice about side effects You may report side effects to FDA at 1-800-FDA-1088 difficult or trouble breathing increased sweating irregular, fast or slow, or shallow breathing lightheadedness, dizziness or fainting loss of consciousness pale or blue lips, fingernails, or skin sleepiness or unusual drowsiness swelling in the legs and ankles Managing side effects (general information)Tapentadol is used to help relieve moderate to severe short-term pain (such as pain from an injury or after surgery) It belongs to a class of drugs known as opioid analgesics It works in the Maximum Daily Dose: 7 5 mg kg day (i e , six 1 25 mg kg doses over 24 hours) Weight 80 kg or greater: Initial Dose: 50 mg orally every 4 hours Maintenance Dose: May titrate stepwise to 75 mg or up to 100 mg orally every 4 hours, if needed, to maintain adequate analgesia with acceptable tolerability reference medscape com drug nucynta-tapentadol-999202--- sciencedirect com topics medicine-and-dentistry tapentadolDrugBank Accession Number DB06204 Background Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake 2, 3 Tapentadol was first approved by the FDA on November 20, 2008 The extended-release formulation of tapentadol was also approved --- webmd com drugs 2 drug-152562-1409 tapentadol-oral details--- drugs com dosage tapentadol html
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